基于聚乙烯醇-海藻酸钠-硼酸并搭载环丙沙星的复合水凝胶的制备及表征
Preparation and Characterization of Composite Hydrogel Based on Polyvinyl Alcohol (PVA)-Sodium Alginate (SA)-Boric Acid (BA) Loaded with Ciprofloxacin
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摘要: 皮肤受到严重创伤时需要很长时间才能修复,伤口敷料作为一种止血剂和细菌屏障,能够控制出血和感染,新型载抗菌药伤口敷料的研发对伤口治疗具有重要意义。为了制备具有自愈合与抗菌能力及优异黏附性能的新型载药水凝胶,本文利用硼酸作为交联剂,制备了一种基于聚乙烯醇(PVA)、海藻酸钠(SA)、硼酸(BA)的复合水凝胶并搭载环丙沙星(CIP)(CIP/PVA-SA-BA复合水凝胶)。通过扫描电子显微镜(SEM)、傅里叶红外光谱对制备的CIP/PVA-SA-BA复合材料进行了系统地表征,并对CIP/PVA-SA-BA复合水凝胶的愈合性、黏附性、溶胀度、释药性及生物相容性能进行考察。CIP/PVA-SA-BA复合水凝胶均呈现出三维多孔结构,在磷酸盐缓冲液中的溶胀度可达869.03 ± 84.56%,具有良好的力学性能。CIP/PVA-SA-BA载药复合水凝胶具有出色的自愈合能力及优异的黏附性能。此外,药物释放实验测试,证实了该水凝胶具有持续的药物释放能力且具有良好的抗菌特性。该研究结果可为载药复合水凝胶在创伤敷料中的应用方面提供参考。Abstract: Severe skin trauma requires a long time to heal, and wound dressings, serving as hemostatic agents and bacterial barriers, can control bleeding and infection. The development of novel antibacterial drug-loaded wound dressings is of great significance for wound treatment. To prepare a novel drug-loaded hydrogel with self-healing, antibacterial, and excellent adhesion properties, this study utilized boric acid as a crosslinker to fabricate a composite hydrogel based on polyvinyl alcohol (PVA) and sodium alginate (SA), boric acid (BA) loaded with ciprofloxacin (CIP) (CIP/PVA-SA-BA composite hydrogel). The prepared CIP/PVA-SA-BA composite materials were systematically characterized by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy, and the healing ability, adhesion, swelling ratio, drug release, and biocompatibility of the CIP/PVA-SA-BA composite hydrogel were evaluated. The CIP/PVA-SA-BA composite hydrogel exhibited a three-dimensional porous structure with a swelling ratio of 869.03 ± 84.56% in phosphate buffer solution and demonstrated good mechanical properties. The CIP/PVA-SA-BA composite hydrogel showed excellent self-healing ability and superior adhesion properties. Additionally, drug release experiments have confirmed that the hydrogel possesses sustained drug release capability and excellent antibacterial properties. These findings provide a reference for the application of drug-loaded composite hydrogels in wound dressings.
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